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Glucagon is classically taught as insulins counter-regulatory partner it is released during fasting and raises blood glucose by stimulating hepatic glucose output

doi: 10.1016/j.jcmgh.2021.04.014 138 RooksMGGarrettWS

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

2017;49:e291

copper accumulation from GHK-Cu is the main driver of the off period