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Blood 117, 59986006 10.1182/blood-2010-11-317024 [DOI] [PMC free article] [PubMed] [Google Scholar] Fornaini G., Magnani M., Fazi A., Accorsi A., Stocchi V., Dacha M

200 Moreover, the current treatments have limited effects on MTB and are accompanied by adverse side effects

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Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]