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In particular, cysteine is the rate-limiting substrate for GSH synthesis

Further studies found that AUF1 interacts with the coding sequence and 3-untranslated region (UTR) of Nrf2 to stabilise the gene, whereas AUF1 binding to the 3-UTR of activating transcription factor 3 ( ATF3 ) promotes degradation of the gene, producing an anti-ferroptosis effect and ameliorating ALI [68]

As with epinephrine and norepinephrine, dobutamine was administered as an initial bolus followed by a constant-rate infusion

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