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doi: 10.1016/0024-3205(81)90374-x 199 GirottiAWThomasJPJordanJE

For instance, LePHGPX in transgenic tobacco plants protected against DNA fragmentation, membrane integrity loss, and oxidative stress induced by necrotrophic fungi, mirroring anti-apoptotic roles observed in animals ( Ferroptosis, a form of iron-dependent lipid peroxidation-mediated cell death, was first described in animals and is regulated by GPX4 (Seibt et al., 2019

Concomitantly, expanded adipose tissue synthesizes and secretes huge amounts of cytokines and chemokines, collectively defined adipochemokines or adipokines, such as leptin, that promote infiltration of adipose tissue by macrophages with subsequent overproduction of RO(N)S and inflammatory cytokines, leading to adipose tissue inflammation (21, 22)

Merad-Boudia M, Nicole A, Santiard-Baron D, Saill C, Ceballos-Picot I

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