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Based on the positive effects reported in previous studies, further testing is warranted in various populations that may benefit from nutritional supplements, including aerobic and anaerobic athletes, resistance-trained individuals, elderly people, and clinical populations, to determine the impact of different doses, timing of ingestion, and long-term and acute effects of Arg, Cit, and CitMal supplements on cardiovascular health and athletic performance

Moreover, several studies suggest that 4-HNE can adduct with LKB1 to inhibit the activity of AMPK and further activate the mTOR pathway, resulting the disabled autophagy initiation [147, 162, 163]

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Grapes and red wine are high in anthocyanins, resveratrol, and flavonoids