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Pathogenesis involves impaired neural crest cell migration, leading to craniofacial dysmorphisms, growth restriction, and central nervous system deficits

In parallel, butyrate also functions as a histone deacetylase (HDAC) inhibitor, influencing epigenetic gene expression ( reg ) differentiation, induce antimicrobial peptide expression (e.g., -defensins, RegIII), and maintain epithelial barrier integrity (Isobe et al., 2020

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10.1016/0012-1606(84)90045-9 [DOI] [PubMed] [Google Scholar] Bowden T

Participants were exposed to 1.2 MEDs narrowband UVB, and outcomes included changes in MED and TT-dimer levels in urine and skin biopsies [31]