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Only BacA induced a significantly higher population of CD4+, CD4+CD45+, and CD8+ cells compared to the uninfected control at 16 weeks post-inoculation ( Figure 5C )

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In fact, patients with MSI-high may greatly benefit from pembrolizumab treatment, as an ORR of 73% was reported in individuals with MSI-high biliary tract cancers, significantly higher than the response rates observed in patients with pancreatic cancer (ORR 30%) 319