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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

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This temporal progression indicates that 5-amino-1MQ may serve as more than a simple enzyme inhibitor, potentially acting as a metabolic reprogramming agent that fundamentally alters cellular energy management strategies over extended periods