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First, The peripheral nerve compression model employed in this study cannot fully replicate key pathological processes such as chronic dorsal root ganglion compression caused by lumbar disc herniation, necessitating further mechanistic validation through more comprehensive disease models in subsequent studies

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The multi-omics characterization is in strong agreement with established pathomechanisms of Parkinson's disease, particularly with respect to mitochondrial dysfunction and protein degradation pathways

Even the natural process of aging itself

69 Although MCT2 mediates neuronal lactate uptake, its inhibition reduces pathological lactylation but also diminishes lactate-induced synaptic protein expression (eg, PSD95, GAP43), ultimately impairing memory consolidation