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To confirm whether clofazimine also inhibits post-entry steps of viral replication, we evaluated the effect of clofazimine on the production of viral RNA by electroporating in vitro-transcribed viral RNA into Vero E6 cells, which bypasses clofazimine-mediated inhibition on the entry process and directly measures RNA synthesis (Extended Data Fig

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

Possible reasons may include the difficulty in distinguishing the effects of endogenous versus exogenous lactate, as well as challenges in translating findings into broad clinical applications

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More than half (52%) of those did not tell their doctor, researchers at the University of Manchester reported in the British Journal of General Practice