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Thrombin cleavage of OPN is a pivotal event that initiates its tumor-promoting activity [270]

According to Wei Zhang et al., halving the number of amino acids in food increases antioxidant capacity and lengthens the life span of Drosophila melanogaster (Zhang et al

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If a patient does not respond to the first-line therapy (amitriptyline, cyproheptadine, and/or propranolol) the following options should be considered: (1) presence of persisting triggers (e.g., psychological stressors) and comorbid conditions (e.g., anxiety, POTS) or missed underlying disorders (e.g., hydronephrosis, chronic sinusitis, acute appendicitis, intestinal malrotation with volvulus, CNS tumors, metabolic crises) and toxic exposure (e.g., cannabis)

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