These high doses, given as a single bolus, may worsen clinical status and are no longer recommended
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The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]
Fusion of the mitochondrial outer membrane involves an irreversible GTPase-driven fusion reaction, primarily based on homotypic or heterotypic oligomeric complexes of Mfn1 and Mfn2, and proceeds through docking, tethering, and elongation steps to achieve contact with the mitochondrial outer membrane (Song et al., 2009)
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