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Within hepatocytes, silymarin shows a high affinity for membrane-bound and nuclear receptors, including PPAR- and CAR/PXR, by enhancing the expression of hepatic detoxification enzymes and improving xenobiotic clearance (Figure 3a) and inhibition of NF-B (Figure 3b), promoting antioxidant defence

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For example, ipamorelin has been shown to counteract the glucocorticoid-induced decrease in bone formation of adult rats and these findings suggest that it may be beneficial in humans [6]