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The measure establishes 30 mL/kg of crystalloid fluids as the default volume for fluid resuscitation but does allow for lesser volumes ordered by a clinician and accompanied ( by documentation of a reason for administering a lesser volume in recognition that some patients may not tolerate 30 mL/kg and that others may respond adequately to a lesser volume

Sources: Dixson et al

Moreover, ROS-dependent angiogenesis can be induced through the activation of this pathway to lead to the expression of HIF1 and VEGF [45]

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It is characterized by a sustained systolic blood pressure (SBP) of 130 mmHg or higher, or a diastolic blood pressure (DBP) of 80 mmHg or higher