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Direct antioxidant defense Cells contain several lines of antioxidant defense against the accumulation and deleterious effects of ROS/RNS (Jomova et al

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Due to the interconnection of glycolysis and Oxphos, there is dynamic interchange between cytoplasmic and mitochondrial NAD + , as depletion of cytoplasmic NMNAT2 also depletes mitochondrial NAD + 77