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Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial

The fentanyl dose-regime consisting of twice daily intravenous injections of 125 mol/kg was based on daily doses used by others 35

Glut1 drives multidrug resistance through dual mechanisms: upregulating drug efflux pumps (P-gp, MRP) to maintain subtherapeutic intracellular drug concentrations and elevating the Bcl-2/Bax ratio to enhance anti-apoptosis capacity

Signal 8, 23

The secondary endpoints include achievement of 20% weight reduction, relative change in body weight, change in waist circumference, change in HbA1c, change in systolic blood pressure, change in the quality of life (IWQOL-Lite-CT), and change in short-form physical functioning score (SF-36v2)