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156 During the past decades, changes in dietary patterns and lifestyle modifications have had potential application in the treatment of AD and have received extensive attention in AD research, including calorie restriction, dietary approaches to stop hypertension, Mediterranean diet, and the KD

Moreover, in line with the role of BHB in supporting OXPHOS in CD8 + T cells 31 we observed similar metabolic changes when human (but not mouse) CD8 + T cells were cultured with BHB (Extended Data Fig

In addition, some dietary interventions, such as restricting calorie and protein intake, have been shown to activate autophagy and protect renal tubular cells (101)

But heres the thing: While some dietary supplements billed as nootropics have some promising science behind individual ingredients, experts largely agree that the use of nootropics by healthy individuals to boost brain health is concerning due to the lack of clinical evidence regarding their efficacy, safety, and social consequences, especially in long-term use (18)