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Studies have shown that hepcidin can enter the central nervous system through the BBB (Raha-Chowdhury et al., 2015), which, with increased permeability after TBI, may allow a large amount of hepcidin to the brain tissue

-LA produces its neuroprotective effect by inhibiting reactive oxygen species formation and neuronal damage, modulating protein levels, and promoting neurotransmitters and anti-oxidant levels

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doi: 10.1111/j.1462-5822.2007.01081.x 151 HirataYNadaYYamadaYToyamaTFukunagaKHwangGWet al

Neurotransmitter Pathways: Functional Clues from Metabolic Precursors Neurotransmitters are synthesized across the central and peripheral nervous systems as well as in peripheral tissues such as the renal system