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Two main hypotheses can be raised to explain lower efficacy of second-line medications [5]: either therapeutic failure is predominantly a marker of severity regardless of the sequence or the use of the first-line biologic is dramatically changing the immune system response [23] limiting the efficacy of a second therapy meaning that therapeutic sequencing is crucial and highly condition the long-term outcomes of patients with UC

These results suggest that anwuligan may promote hair regeneration in mice by activating the Wnt/-catenin signaling pathway via Ctnnb1

Pathogenesis Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity

Kim T-H, Kim D-H, Lee SG

Haykal D, Cartier H, Drno B