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Future research should critically evaluate whether sufficient active curcumin (or its metabolites) reaches oral or systemic target tissues at pharmacologically relevant concentrations in humans, and whether observed clinical benefits correlate with biologically plausible exposureresponse relationships

2.3.4 Real-time detection/BCI 2.3.4.1 Threshold algorithm 2.3.4.1.1 Calibration The threshold for PN detection was computed using the mean and standard deviation for the first second of the rest portion of the calibration ERP from the central Cz electrode, characterized by a low likelihood of Peak Negativity occurrence

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Together, providing the innate harmful effect of NOS blocker L-NAME itself, these findings may emphasize the positive significance of NO in protecting retinal neurons (and thereby, harmful effect of NOS-blockers ( Furthermore, it was demonstrated that NO is continuously produced in the retina and essential for maintenance of retinal blood flow (Vukojevic et al., 2018