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In Beclin1-deficient HCT116 colonic epithelial cells, the expression level of LRRK2 is elevated, suggesting that autophagy inhibition may upregulate LRRK2

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The pathophysiology of severe asthma with persistent airflow limitation shares similar features with that of chronic obstructive pulmonary disease (COPD), including airway remodeling and emphysema-like changes, which complicate diagnosis and treatment [42]