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Antioxidant activity, metabolism, and bioavailability of polyphenols in the diet of animals

showed in their study that, upon infection of mice engrafted with human immune cells carrying HLA-DR15+ or HLA-DR15- (DR4), EBV viral load and CD8 T cell expansion were higher in those HLA-DR15+ mice, and myelin basic protein-specific CD4 T cells were only detected in HLA-DR15+ mice (121, 122)

Godin-Ethier, J., et al

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It was subsequently proposed that CO might affect oxygen sensing by locking the sensor in an oxy conformation, which could involve a multisubunit mechanism [5965] (Fig