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Their peptide levels matter too

scavenges superoxide anion Anti-proliferative effect - inhibits smooth muscle hyperplasia Because of the above actions of NO, when its production is impaired or its bioavailability is reduced, the following can result: Vasoconstriction (e.g., coronary vasospasm, elevated systemic vascular resistance, hypertension) Thrombosis because of platelet aggregation and adhesion to vascular endothelium Inflammation because of upregulation of leukocyte and endothelial adhesion molecules Vascular hypertrophy and stenosis Diseases or Conditions Associated with Abnormal NO Production and Bioavailability Hypertension Obesity Dyslipidemias (particularly hypercholesterolemia and hypertriglyceridemia) Diabetes (both type I and II) Heart failure Atherosclerosis Aging Cigarette smoking Revised 01/05/2018

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Chem., 2004, 43, 36953699

When the GSH-dependent lipid peroxide repair system is damaged, it causes ferroptosis through the fatal accumulation of lipid-reactive oxygen species [20, 41,42,43]