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J Dent Res 99(2):143151

We then used the Cdkn2a + Cdkn1a + MuSCs and progenitors as a candidate cell population to evaluate broader senescence signatures at the single-cell level

Recent data has shown that the expression of the NAD(P)H oxidase subunits Nox4 and p22phox are upregulated in the kidney of STZ-induced diabetic rats and that NAD(P)H oxidase-dependent production of ROS may cause DNA damage in diabetic renal tissues leading to the development of nephropathy [26]

Despite these limitations, Mel injection therapy has demonstrated significant potential in rat models, similar to the effects seen with corticosteroid injections and platelet-rich plasma (PRP) treatments for knee joints (Wu et al., 2023)

1 to 3 years between ages 40 and 54