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Delphi Survey Rounds The questions that received consensus in the first survey (Table S4) were revised and used in the second survey (Table S5)

Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage (Sies, 2015) that harm lipids, proteins and DNA (Schieber and Chandel, 2014)

3 Mood regulation Vitamin B12 is essential for the synthesis of neurotransmitters that regulate mood

The choice of solvent dramatically impacts both immediate solubility and long-term stability

1 Conclusion and perspective It is hoped that this review and our idea can provide a reference for most newly diagnosed patients with T2D receiving hypoglycemic therapy