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Simvastatin induces G(1) arrest by up-regulating GSK3 and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells

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Adverse events that cause death, persistent incapacity, induce congenital disabilities, or other serious injury are known as serious adverse events, while those that occurred during the clinical trial but may not have been related to the therapeutic under investigation are instead categorized as adverse reactions