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Moreover, 5 mg/kg 3-bromopyruvate (glycolysis inhibitor) in a mouse with arthritis induced by K/BxN mouse serum reduces clinical score, proinflammatory cytokines in the joint, inflammatory cell infiltration, joint destruction, and cartilage damage 27 , which has made it possible to consider glycolysis pathway inhibition as a potential pharmacological target for RA 29

Tehlivets O, et al

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J Funct Foods 40:249260 Li S, Liu H, Wang W, Wang X, Zhang C, Zhang J, Jia L (2018) Antioxidant and anti-aging effects of acidic-extractable polysaccharides by Agaricus bisporus