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may reveal air trapping and bronchial thickness Differential diagnoses For more information on the differential diagnoses below, see Differential diagnosis of chronic cough, Differential diagnosis of dyspnea, Differential diagnosis of acute asthma, and Wheezing in children. Pulmonary COPD or asthma-COPD overlap Exercise-induced bronchoconstriction Allergic bronchopulmonary aspergillosis Cystic fibrosis Primary ciliary dyskinesia Bronchiectasis 1-antitrypsin deficiency Interstitial lung disease Central airway obstruction Infection, e.g., tuberculosis, pertussis Reactive airway disease Cardiac Upper respiratory Upper airway cough syndrome Laryngeal obstruction (e.g., inhaled foreign body) Vocal cord dysfunction Gastrointestinal: GERD Other Adverse effect of medication, e.g., cough due to ACE inhibitors Hyperventilation Consider allergic bronchopulmonary aspergillosis if respiratory symptoms worsen and/or features of bronchiectasis develop despite asthma treatment

Powell LW, Seckington RC, Deugnier Y

1 NAC also brings its own antioxidant powers to the table

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J

has served as a consultant to AstraZeneca, Otsuka Pharmaceutical, Glaxosmithkline, Janssen Cilag, Lundbeck Merck and Servier