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Nonalcoholic fatty liver disease (NAFLD) is a global health issue, affecting nearly a 32 percent of adults 40 percent of men and 26 percent of women, according to the National Institutes of Health (NIH)

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adverse or undesired effects Examples -- positive, beneficial drug interaction effects: Propranolol + hydralazine (reflex tachycardia (undesirable) caused by hypotensive hydralazine-mediated response is prevented by propranolol-mediated -adrenergic receptor blockade Opioid-induced respiratory depression may be counteracted by administration of the opioid receptor antagonist naloxone Adverse effects -- toxic reactions One drug may interact with another to impede absorption One drug may compete with another for the same plasma protein-binding sites One drug may affect metabolism of another by either enzyme induction or enzyme inhibition One drug may change the renal excretion rate of the other

demonstrated that hypoxia at high altitude causes adverse effects on sperm quality and reproductive hormones, and these effects are reversible [47]

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