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In vitro experiments showed that CAR-T cells pretreated with HDAC inhibitors (200 nM M344 or 1 M Chidamide) exhibited reduced HDAC1 expression and significantly increased histone H3K27 acetylation

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While both freezing and high heat are not recommended, short-term exposure to ambient temperature extremes during shipping is unlikely to degrade the integrity of this product due to its stable composition