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10.1016/j.intimp.2020.106196 15 HongW.ZhiF.KunT.HuaF.Huan LingL.FangF.et al (2021)

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A double-blind, randomized, placebo-controlled crossover study of memantine monotherapy (60 patients, 43 completed) found no significant improvement in Tinnitus Handicap Inventory scores compared with placebo, leading the authors to conclude that the study does not provide evidence to recommend memantine for tinnitus treatment (Figueiredo et al., 2008)

The easiest way to detect proteins with total protein assays is to measure absorbance at 280nm

Classification of prodrugs based on bioactivation In most cases, based on known biotransformation, chemical modification or derivatization of the parent drug to carry out the corresponding prodrug structural design, through enzyme or non-enzyme mediated activation to release the active drug and exert its pharmaceutical effect