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Inactivation of the detoxifying enzyme glutathione -S- transferase has been observed in cells exposed in vitro to busulfan and, because of the inactivation of the enzyme, the level of free electrophilic species in the tissues of the exposed organisms can increase to levels that irreversibly damage the cell, which is deranged to apoptotic or necrotic death

doi: 10.3390/ijms151018677 196 CarelKKummerJLSchubertCLeitnerWHeidenreichKADrazninB

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Among them, there are different types of compounds with different places amodesode of action and varied final effects (Sharifi-Rad et al., 2022)

However, there are few studies regarding this topic, probably because the complete repertoire of isoenzymes has not been elucidated in the species of interest