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Notably, it has been reported that melatonin MT1 receptors prevent -syninduced ferroptosis in Parkinsons disease through activation of the SIRT1/Nrf2/HO-1/GPX4 pathway [40], which is consistent with our findings and further supports the potential of SIRT1 activation as a strategy to suppress ferroptosis

Ferroptosis, an iron-dependent form of RCD driven by GSH depletion and GPX4 inactivation, is potently accelerated by copper through multi-pronged mechanisms that converge on iron-dependent lipid peroxidation [61, 62]

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Liu, X., Lin, J., Zhang, H., Khan, N