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Carnitine that is not absorbed by the small intestine can make it all the way down to the colon, where some types of bacteria can break it down, releasing a by-product called TMA (trimethylamine)

To make matters worse, by 2025 the number of men suffering from erectile dysfunction (ED) is expected to double, Science Direct finds

Constipation may also predispose bacteria to reach excessive populations, particularly Lactobacillus species that can execute tyrosine decarboxylation, L-DOPA by converting it into dopamine in the gut hence limiting its release into the bloodstream and causing motor fluctuations (Menozzi and Schapira, 2024)

In a randomized controlled trial published in Gut Microbes (2019), participants supplemented with liposomal glutathione and vitamin C exhibited significant improvements in gastrointestinal symptoms and microbial diversity compared to the placebo group

This may lead to fracture and tibial pseudarthrosis (non-union)