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This concept may be more plausible in the light of the emerging understanding of the functional matrix of the brain [for a review, see (Stam, 2014) and (Nichols et al., 2017)]

Furthermore, -hydroxybutyrate counteracted the proliferative effects of carnitine and acetylcarnitine by activating FXR and modulating the PPAR/PGC1/CPT1A axis

Plates were mixed for 2 min to induce cell lysis and incubated for 10 min at room temperature

These findings demonstrate that epigenetic mechanisms can reestablish pro-survival signaling outputs in the absence of new mutations, providing a flexible defense mechanism that operates independently of genotype