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doi: 10.1016/j.jplph.2007.02.005 79 KumarM

Some of these will be mild, like flatulence, cramping, or constipation, whilst others can be more severe

For example, exosomes derived from skeletal muscle have been shown to suppress macrophage inflammatory responses by upregulating the immune-responsive gene 1 (IRG1) pathway, which boosts itaconate production 42