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20), indicating that M1EV has a potent macrophage polarization effect

Nrf2/ARE-dependent genes code for numerous mediators of the antioxidant response, including GCL, glutathione S-transferases (GSTs), thioredoxin, NAD(P)H quinone oxidoreductase 1 (NQO-1), and heme oxygenase 1 (HO-1) (21)

P., Schmelzer, J

The challenge, though, is deciding the best way to supplement

It also shows insufficient capacity to remove apoptotic bodies, protein aggregates and myelin, contributing to the accumulation of potentially toxic agents (Safaiyan et al., 2016)