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In the context of CKD, iron deposition is accompanied by the increased expression of iron input proteins (ZRT/IRT-like proteins, ZIP14 and ZIP8) or the decrease in FPN1 expression, indicating that iron accumulation may be triggered by increased iron uptake or insufficient iron efflux (Fig

Pest Biochem Physiol 59:3549 Cummins I, Cole DJ, Edwards R (1999) A role for glutathione transferases functioning as glutathione peroxidases in resistance to multiple herbicides in black-grass

Tumor Suppressors: In some cancer types, p53 suppresses GLS activity

Pro-inflammatory mediators such as cytokines induce the expression of inducible nitric oxide synthase (iNOS) and increased NO production can combine with ROS to form peroxynitrate, which is a potent inhibitor of mitochondrial respiration and energy production (Nesci et al., 2021)

They are short chains of amino acidsthe very building blocks of proteinthat instruct your cells to perform specific jobs