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Summary: Cagrilintide and retatrutide are investigational injectable medicines being studied for obesity and type 2 diabetes in men, targeting multiple hormonal pathways to reduce appetite, improve blood glucose control, and increase energy expenditure, but neither is currently licensed in the UK

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What the semaglutide trials established Semaglutide sits within the GLP-1 receptor agonist class (alongside liraglutide and dulaglutide), with tirzepatide representing the GIP/GLP-1 dual agonists