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Differentiating Tregs recognise their cognate antigens and receive T-cell receptor (TCR) signals before initiating Foxp3 transcription, which is triggered by TCR-induced transcription factors including NFAT, AP-1 and NF-B

Apart from this successful clinical trial, few modern trials use the IM route for iron chelation in brain disorders, likely due to the availability of IV infusion pumps and controlled-release devices that slow down the rapid elimination profile of DFO

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Sestrin2 as a potential target for regulating metabolic-related diseases