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38,39,40 The approval of both BCG and pembrolizumab for carcinoma in situ of the bladder manifested that immunotherapy can play a role in cancer chemoprevention

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Nickel agarose (left), streptavidin agarose (middle), and glutathione agarose (right), are used to detect interactions with his-tagged, strep-tagged, and GST-tagged target proteins, respectively

Even though radiation therapy is often used in combination with surgery and chemotherapeutic modalities to increase the anti-tumor effect, long term cancer survivors have a higher risk for developing second malignancies because the radiation does also harm genetic material of healthy tissue (Dracham et al., 2018)