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Recently, following oxidative stress, DJ-1 was shown to be involved in the oxidative stress response that leads to the upregulation of the proteasome, thus inhibiting its activity and rescuing partially unfolded proteins from degradation (Moscovitz et al., 2015)

This decrease may be at least in part due to neuronal apoptosis as demonstrated by increased caspase3 expression in the diabetic spinal cord group, similar to the results of The mechanisms underlying neuronal apoptosis may be the disruption of the Nrf2/HO-1 and NF-kB pathways

Imielski Y, Schwamborn JC, Luningschror P, Heimann P, Holzberg M, Werner H, Leske O, Puschel AW, Memet S, Heumann R, et al

Gross motor development was delayed

Dagogo-Jack S