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Introduction Aging is a substantial risk factor for the development of inflammatory conditions, such as osteoarthritis (OA) and, probably, other degenerative, and neoplastic diseases of the bone, such as Paget disease of the bone and osteosarcoma ( Insulin/IGF1R Signaling Pathway The insulin/IGF-1 signaling system (IIS) is the route that regulates not only the organism's metabolism, but also the growth, development, and longevity concerning the availability status of nutrients

38 , e102147 (2019)

As the most important antioxidant system, glutathione can be an important part of the therapeutic process by preventing cell damage

Delivery of repRNA into cells promotes synthesis of antigen-encoding RNA that self-adjuvants by triggering innate immune responses and promoting antigen cross-priming which enhances humoral and cellular immune responses compared to conventional mRNA

J., Powell, T