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Clementi A, Virz GM, Milan Manani S, Battaglia GG, Ronco C, Zanella M

Specifically targeting lactylation without affecting other acylations is crucial for achieving therapeutic effects and avoiding unintended side effects

Because of this, higher doses, typically 5001,000 mg per day, are often required to see measurable benefits (NIH)

Additionally, PKM2 seems to play an important role in EC function and angiogenesis as silencing of PKM2 resulted in decreased sprouting (Gmez-Escudero et al., 2019), but also in reduced VE-cadherin expression resulting in destabilization of the cellular junctions (Gmez-Escudero et al., 2019)

Vitamin C also helps in: Iron absorption, prevents iron deficiency anemia