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95% of the values fall within two standard deviations from the mean

PloS One 2016, 11 (6), e0157847

PFIC are paediatric manifestations, but the same variants causing PFIC can also cause cholestasis with a later paediatric onset or adult-onset cholestatic disease (AOCD)

10.1152/ajpendo.00424.2019 Am J Physiol Endocrinol Metab

In the context of the so-called microbiotagutbrain (MGB) axis, it is shown to have a strong influence on host neuromodulation and endocrine functions (i.e., controlling the synthesis of neurotransmitters like serotonin or mediating the activation of the hypothalamicpituitaryadrenal axis), as well as in modulation of host immune responses, critically regulating intestinal, systemic and brain inflammation (neuroinflammation)