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Genetic and biochemical data have shown that LRRK2 pathogenic variants particularly Gly2019Ser and variants in the GTPase Roc and COR domains of the protein cause a toxic, gain-of-function-mechanism mediated hyperactivity of LRRK2 kinase (Chan et al

[0273] In some embodiments, the compositions comprise a cannabinoid (e.g., CBD) and a cofactor or precursor thereof (e.g., niacinamide) at a molar ratio of between about 50:1 and about 1:80

doi: 10.1016/j.meafoo.2024.100143 204 Carrin-AntolABadiche-El HilaliFLorente-MentoJMDaz-MulaHMSerranoMValeroD

13, June 2021, p

Dietary phenolic acids act as effective antioxidants in membrane models and in cultured cells, exhibiting proapoptotic effects in leukaemia cells